Synthesis of Enantioenriched Alkylfluorides by the Fluorination of Boronate Complexes.
نویسندگان
چکیده
The enantiospecific conversion of chiral secondary boronic esters into alkylfluorides is reported. Boronate complexes derived from boronic esters and PhLi were used as nucleophiles, with Selectfluor II as the electrophilic fluorinating agent, to afford alkylfluorides in short reaction times. The addition of styrene as a radical trap was found to enhance enantiospecificity. A broad range of alkyl boronic esters were converted into alkylfluorides with almost complete enantiospecificity by this method.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 137 32 شماره
صفحات -
تاریخ انتشار 2015